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KMID : 0370220230670030137
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Yakhak Hoeji
2023 Volume.67 No. 3 p.137 ~ p.144
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Lipid-based Liquid Crystalline Phases for Biocompatible and Versatile Drug Delivery
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Kim Sung-Hyun
Seo Min-Joon
Lim Hyung-Sik
Hong Jin-Tae
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Abstract
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The purpose of the paper was to overview the liquid crystalline phases that can be prepared with various lipidsand to assess their characteristics as drug delivery systems for drugs to be administered to various routes. Glycerylmonooleate (GMO) was most frequently employed to deliver the drugs to topical, transdermal, oral, buccal and parenteralroutes. In addition to bulk phase such as lamellar and cubic liquid crystalline phases, nano-sized cubosomes of GMO haveoffered a wide range of chances to administer drugs more precisely to oral and parenteral routes. In addition to GMOdifferent types of lipids including phospholipids, triglycerides, fatty acids and cholesterol were able to form liquidcrystalline phases even though most studies employing other lipids than GMO were focused on revealing their phasebehaviors and physicochemical characteristics. However, it was expected that more research attempts will be made onutilizing new class of liquid crystalline phases that can be formed with various lipids. Based on the outcome published todate, more versatile drug delivery can be possible if new lipid materials can be developed and used to organize uniquemolecular orders suitable for a difficult-to-carry drugs.
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KEYWORD
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Lipid, Liquid crystalline phases, Drug delivery, Glyceryl monooleate
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